Opportunity Information: Apply for PAR 18 107
The National Institutes of Health (NIH) funding opportunity titled "Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34 Clinical Trial Required)" (Funding Opportunity Number PAR-18-107) supports early-stage, real-world research aimed at improving how diabetes and obesity are prevented and treated within routine healthcare environments. The core idea is to fund planning and pilot work that helps investigators develop, refine, and test practical intervention approaches that can actually function in everyday clinical settings, rather than idealized research conditions. This is an R34 mechanism, which is typically used to generate the groundwork and preliminary evidence needed to justify and design a larger, full-scale clinical trial later on.
Projects under this FOA are expected to focus on pragmatic strategies that healthcare systems can sustain over time, with an emphasis on improving both care processes and patient health outcomes for people who have diabetes or obesity, or who are at elevated risk for developing these conditions. The announcement explicitly encourages work that is adapted to the realities of healthcare delivery, meaning applicants should be thinking about feasibility, workflow fit, scalability, cost considerations, and the kinds of barriers and facilitators that matter to clinics, hospitals, and health systems. The pilot study is meant to produce actionable data. If the pilot results look promising, the R34 findings should be strong enough to support a subsequent full-scale trial intended to change routine practice and potentially inform healthcare policy related to diabetes and obesity prevention and management.
A key requirement is that this opportunity is "Clinical Trial Required," meaning the funded planning and pilot activities must include a clinical trial component rather than being purely observational or purely developmental without testing. In practice, that typically means applicants need to propose a structured evaluation of an intervention approach, even at a pilot scale, and collect outcomes that speak to both implementation success and clinical or behavioral impact in the target population.
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits (both with and without 501(c)(3) status); for-profit organizations (other than small businesses); and small businesses. The FOA also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal government agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. At the same time, it clearly restricts foreign involvement: non-U.S. (foreign) organizations and foreign institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
From an administrative standpoint, this is a discretionary grant in the health and food/nutrition space (CFDA 93.847). The listed award ceiling is $150,000. The opportunity was created on November 21, 2017, and the original closing date shown is September 17, 2018. Overall, the grant is positioned as a stepping-stone mechanism: it funds the preparatory and pilot-testing work needed to move a promising, implementation-ready strategy toward a larger pragmatic trial that can meaningfully improve diabetes and obesity care in real healthcare settings.Apply for PAR 18 107
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2017-11-21.
- Applicants must submit their applications by 2018-09-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34 Clinical Trial Required)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAR-18-107.
What is the main purpose of this grant?
This grant supports early-stage planning and pilot work for pragmatic, real-world research designed to improve how diabetes and obesity are prevented and treated in routine healthcare settings. The intent is to help investigators develop, refine, and test practical intervention approaches that can function in everyday clinical care, not just under ideal research conditions.
What does "pragmatic research in healthcare settings" mean in this FOA?
In this FOA, "pragmatic" refers to intervention strategies that fit real clinical workflows and the realities of healthcare delivery. Projects are expected to consider feasibility, workflow fit, scalability, cost considerations, and real-world barriers and facilitators that clinics, hospitals, and health systems face.
What is the R34 mechanism and how is it used here?
This is an R34 planning grant mechanism, which is typically used to generate groundwork and preliminary evidence needed to justify and design a later, larger full-scale clinical trial. Under this FOA, the R34 supports preparatory activities and pilot testing intended to produce actionable data.
Is a clinical trial required under this opportunity?
Yes. The FOA is explicitly "Clinical Trial Required," meaning the funded planning and pilot activities must include a clinical trial component rather than being purely observational or purely developmental without testing.
What does "Clinical Trial Required" imply for the project design?
It implies that applicants should propose a structured evaluation of an intervention approach, even at a pilot scale, and collect outcomes that speak to both implementation success and clinical or behavioral impact in the target population.
What health topics must the project focus on?
Projects are expected to focus on improving diabetes and obesity prevention and care, including work aimed at people who have diabetes or obesity and people at elevated risk of developing these conditions.
What kinds of outcomes does NIH emphasize for these projects?
The FOA emphasizes improving both care processes and patient health outcomes. It also highlights the need to gather outcomes related to implementation success as well as clinical or behavioral impact.
What types of settings are these projects intended for?
The projects are intended for routine healthcare environments, such as clinics, hospitals, and broader healthcare systems, with approaches designed to work under everyday conditions.
What types of activities are expected during the R34 period?
The FOA supports planning and pilot activities, including developing, refining, and pilot testing intervention approaches and generating actionable data that can support a later full-scale pragmatic trial.
Is this funding meant to support a full-scale trial?
No. It is positioned as a stepping-stone mechanism. The R34 funds preparatory and pilot-testing work intended to support and inform a subsequent larger, full-scale clinical trial if pilot results are promising.
How should applicants think about sustainability and long-term use by healthcare systems?
The FOA expects projects to focus on pragmatic strategies that healthcare systems can sustain over time, including attention to workflow fit, scalability, and cost considerations that influence whether an approach can be maintained as routine practice.
What kinds of barriers and facilitators should projects consider?
Applicants are encouraged to address real-world barriers and facilitators that matter to clinics, hospitals, and health systems, such as feasibility within routine care, how the intervention fits into workflows, and practical considerations that affect uptake and delivery.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and governmental entities. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits (with and without 501(c)(3) status); for-profit organizations (other than small businesses); and small businesses.
Are any additional types of applicants specifically highlighted as eligible?
Yes. The FOA highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible federal government agencies; faith-based or community-based organizations; regional organizations; and U.S. territories or possessions.
Are foreign organizations eligible to apply?
No. Non-U.S. (foreign) organizations and foreign institutions are not eligible to apply.
Can a U.S. organization include a non-U.S. component?
No. Non-U.S. components of U.S. organizations are not eligible under this FOA.
Are foreign components allowed if defined as a "foreign component" under NIH policy?
No. The FOA states that foreign components (as defined by NIH policy) are not allowed.
What is the maximum award amount listed for this opportunity?
The listed award ceiling is $150,000.
What type of grant is this from an administrative standpoint?
It is described as a discretionary grant in the health and food/nutrition space.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.847.
When was this opportunity created?
The opportunity was created on November 21, 2017.
What closing date is shown for the opportunity?
The original closing date shown is September 17, 2018.
What is NIH ultimately trying to enable through this R34?
NIH is aiming to enable investigators to generate planning outputs and pilot data strong enough to justify, design, and pursue a later full-scale pragmatic trial that could change routine practice and potentially inform healthcare policy related to diabetes and obesity prevention and management.
What makes a project a good fit for this FOA based on the description provided?
A good fit is a project that pilot-tests a practical intervention in real healthcare settings, includes a clinical trial component, produces actionable implementation and health outcome data, and is designed with feasibility, workflow integration, scalability, sustainability, and cost considerations in mind.
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| Funding Opportunity |
|---|
| Elucidating HIV and HIV-treatment Associated Metabolic/Endocrine Dysfunction (R01 Clinical Trial Optional) Apply for RFA DK 17 036 Funding Number: RFA DK 17 036 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Pilot and Feasibility Therapeutic Clinical Trials in Diabetes, and Endocrine and Metabolic Diseases (R21- Clinical Trial Required) Apply for PA 18 405 Funding Number: PA 18 405 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| NIDDK Exploratory Clinical Trials for Small Business (R44 Clinical Trial Required) Apply for PAR 18 108 Funding Number: PAR 18 108 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34 Clinical Trial Optional) Apply for PAR 18 423 Funding Number: PAR 18 423 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $225,000 |
| NIDDK Multi-Center Clinical Trial Cooperative Agreement (U01 Clinical Trial Required) Apply for PAR 18 415 Funding Number: PAR 18 415 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Innovative Research in HIV in Kidney, Urology, and Hematology (R01 Clinical Trial Optional) Apply for RFA DK 17 037 Funding Number: RFA DK 17 037 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| NIDDK Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed) Apply for PAR 18 414 Funding Number: PAR 18 414 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Mentored Research Scientist Development Award (K01-Clinical Trial Required) Apply for PAR 18 418 Funding Number: PAR 18 418 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| NIDDK Mentored Research Scientist Development Award (K01-No Independent Clinical Trials) Apply for PAR 18 419 Funding Number: PAR 18 419 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| High Impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional) Apply for PAR 18 111 Funding Number: PAR 18 111 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Academic Research Enhancement Award in Diseases within the Mission of NIDDK (R15 - Clinical Trial Required) Apply for PA 18 495 Funding Number: PA 18 495 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Microphysiological Systems (MPS) for Modeling Diabetes (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA DK 17 035 Funding Number: RFA DK 17 035 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Ancillary Studies to the NIDDK Inflammatory Bowel Disease Genetics Consortium (R21 - Clinical Trial Optional) Apply for RFA DK 17 018 Funding Number: RFA DK 17 018 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $150,000 |
| Ancillary Studies to the NIDDK Inflammatory Bowel Disease Genetics Consortium (R01- Clinical Trial Optional) Apply for RFA DK 17 017 Funding Number: RFA DK 17 017 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Support for Small Business Innovation Research to Develop New Open and Closed-Loop Automated Technologies for Better Type 1 Diabetes Therapy and Monitoring (SBIR) (R43/R44- Clinical Trial Not Allowed) Apply for RFA DK 17 029 Funding Number: RFA DK 17 029 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Development of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/44 Clinical Trial Not Allowed) Apply for RFA DK 17 030 Funding Number: RFA DK 17 030 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Underactive Bladder and Detrusor Activity in Aging (R01 Clinical Trial Optional) Apply for PA 18 570 Funding Number: PA 18 570 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Pilot and Feasibility Studies of HIV and Animal Models for HIV Infection within the Mission of NIDDK (R21 Clinical Trial Optional) Apply for PA 18 615 Funding Number: PA 18 615 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Limited Competition for the Continuation of the Clinical Centers for The Environmental Determinants of Diabetes in the Young (TEDDY) Study (U01 Clinical Trial Not Allowed ) Apply for RFA DK 17 511 Funding Number: RFA DK 17 511 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,100,000 |
| Mass Spectrometric Assays for the Reliable and Reproducible Detection of Proteins/Peptides of Importance in Type 1 Diabetes Research (U01 Clinical Trial Not Allowed) Apply for RFA DK 17 019 Funding Number: RFA DK 17 019 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $350,000 |
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