Childhood Asthma in Urban Settings -Clinical Research Centers (U01 Clinical Trial Optional) | RFA AI 19 073

Opportunity Information: Apply for RFA AI 19 073

The Childhood Asthma in Urban Settings - Clinical Research Centers (U01 Clinical Trial Optional) opportunity (RFA AI 19 073) is a National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) funding announcement designed to build and support a coordinated clinical research network focused on pediatric asthma in low-income urban communities. The main aim is practical and outcomes-driven: the funded Clinical Research Centers, referred to as CAUSE-CRCs, are expected to run clinical studies and clinical trials that can lead to better treatment strategies and, where possible, prevention approaches that actually work for children living in urban settings where asthma burden is often highest and care barriers are common.

This award uses the cooperative agreement mechanism (U01), which generally means the work is not conducted in isolation. Instead, funded sites operate as part of a structured network with active collaboration and substantial involvement from NIAID and network leadership. Within this network model, CAUSE-CRCs are expected to carry out two broad types of research activity. First, they will participate in network-wide clinical research projects, meaning multi-site studies where consistent protocols, shared outcomes, and centralized coordination matter. Second, they may also conduct site-specific studies, allowing individual centers to pursue locally driven questions or interventions that still align with the overall network mission. Clinical trials are described as optional, indicating that applications may propose trials if appropriate, but the scope can include other forms of clinical research as well.

A central feature of the program is close coordination with the CAUSE Leadership Center (CAUSE-LC). For network-wide projects and key network functions, the CAUSE-CRCs are expected to work hand-in-hand with this Leadership Center, which typically supports core activities such as protocol development and harmonization, operational oversight, data coordination, quality control, recruitment strategies, and cross-site communication. In practical terms, applicants should expect a high level of collaboration, shared decision-making, and adherence to network standards, since the goal is to generate findings that are strong enough to inform real-world care for vulnerable pediatric populations.

Eligibility for this FOA is broad across many U.S.-based organization types. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and a wide range of nonprofit organizations (both with and without 501(c)(3) status). The FOA also allows applications from for-profit organizations (other than small businesses) and small businesses, as well as public housing authorities and Indian housing authorities. Tribal eligibility is explicitly included, covering federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized tribal governments. The announcement also highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and regional organizations. U.S. territories or possessions are also included among eligible applicants.

At the same time, the FOA draws clear boundaries around non-U.S. participation. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply directly. Non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined under the NIH Grants Policy Statement, meaning a U.S. applicant may include certain foreign collaborations or activities if they meet NIH policy requirements, even though the applicant organization itself must be domestic.

From an administrative standpoint, this is categorized as a discretionary funding opportunity in the health area, listed under CFDA number 93.855. The original closing date provided in the source information is June 19, 2020, and the record shows a creation date of January 29, 2020. The listed award ceiling is $300,000. (The expected number of awards is not specified in the provided source data.) Overall, the opportunity is structured to create a functioning clinical research network that can rigorously test and refine interventions and care approaches for childhood asthma in urban, low-income environments, with an emphasis on collaborative, multi-site work coordinated through a central leadership hub.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Childhood Asthma in Urban Settings -Clinical Research Centers (U01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
• This funding opportunity was created on 2020-01-29.
• Applicants must submit their applications by 2020-06-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $300,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA AI 19 073

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: