Opportunity Information: Apply for PAR 18 767
The Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) opportunity (PAR 18-767) is a National Institutes of Health funding program led through the National Cancer Institute that supports long-term, structured partnerships between NCI-designated Cancer Centers (CCs) and institutions that serve underserved health disparity populations and educate underrepresented students (referred to as ISUPSs). It uses a cooperative agreement mechanism (U54), which typically means NIH program staff have an active role in overseeing and shaping the work as it progresses, rather than operating strictly as a hands-off grant. The overall intent is to strengthen the national cancer research enterprise while directly addressing persistent gaps in cancer outcomes, research participation, training access, and community benefit for populations that have historically been left out of cancer research and cancer-care advances. Clinical trials are optional under this announcement, meaning projects may include clinical trial activities when appropriate, but they are not required.
At the center of CPACHE is the idea that durable, mutually beneficial institutional partnerships can build capacity where it is most needed and can also make established cancer centers more effective in disparities-focused science. The program expects partners to work as a unified team to improve research infrastructure, training pipelines, mentorship, and community engagement in ways that last beyond the award period. Rather than funding isolated projects, CPACHE emphasizes comprehensive collaboration that integrates research, education, and outreach. In practice, this often translates into shared leadership and decision-making, coordinated cores or shared resources, cross-institutional mentoring teams, joint seminars and training activities, and collaborative research projects that are explicitly relevant to cancer inequities affecting surrounding communities.
The required goals of the partnership are clearly spelled out and cover four main areas. First, the partnership must increase cancer research and cancer research education capacity at the ISUPS institution(s). This can include strengthening faculty research capability, improving access to modern methods and technologies, expanding grant readiness, building sustainable mentorship networks, and enhancing educational offerings that prepare trainees to participate in competitive cancer research. Second, the program aims to increase the number of students and investigators from underrepresented populations who engage in cancer research, reflecting a workforce and pipeline objective that prioritizes recruitment, retention, training quality, and advancement. Third, CPACHE seeks to improve the ability of the NCI-designated Cancer Center to develop and sustain robust research programs focused on cancer health disparities, while also increasing the number of investigators and students (across the partnership) doing cancer disparities research. Fourth, the partnership must develop and implement cancer-related activities that provide tangible benefits to underserved communities, reinforcing that community impact is not an add-on but a core expectation. These community-oriented activities can include outreach, education, evidence-based interventions, research participation initiatives, navigation-related programming, or other locally responsive efforts that align with the partnership's strengths and the community's needs.
Eligibility for CPACHE is broad in terms of U.S.-based organizations, reflecting the program's interest in building cross-sector alliances that can sustain equity-focused work. Eligible applicants include multiple levels of government (state, county, city or township, special districts), independent school districts, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities, nonprofits with or without 501(c)(3) status, for-profit organizations (other than small businesses) and small businesses, and other entities as allowed. The announcement also calls out categories of organizations that commonly align with the ISUPS role or community engagement role, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also explicitly mentions faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies as potential applicants or partners, underscoring the flexibility to build partnerships that match local context and population needs.
There are clear restrictions related to foreign involvement. Non-domestic (non-U.S.) entities are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply under this opportunity. In addition, foreign components, as defined by the NIH Grants Policy Statement, are not allowed. In practical terms, the partnership and the supported activities must remain domestically based without foreign organizational components.
From an administrative standpoint, the opportunity is categorized under Education and Health, and it is associated with multiple CFDA numbers (93.393 through 93.399), reflecting its alignment with NCI programs across research, training, and related cancer initiatives. The funding instrument is a cooperative agreement, reinforcing that awardees should anticipate ongoing coordination with NIH staff, performance monitoring, and programmatic involvement consistent with U54 expectations. The original closing date listed for the provided record is January 11, 2021, and the source information does not specify an award ceiling or the expected number of awards, so those details would normally need to be confirmed through the full funding announcement or current NIH/NCI postings if the program is being reissued or continued under a related notice.
In short, CPACHE is designed to build sustained institutional partnerships that simultaneously (1) strengthen research and education capacity at institutions serving underserved and underrepresented groups, (2) grow and support a more diverse cancer research workforce, (3) deepen and expand cancer center leadership and productivity in cancer health disparities research, and (4) deliver meaningful cancer-focused benefits to underserved communities, all within a U.S.-based framework and with clinical trial participation available but not required.Apply for PAR 18 767
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (Collaborative U54 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.397, 93.398, 93.399.
- This funding opportunity was created on 2018-04-30.
- Applicants must submit their applications by 2021-01-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs) - Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (PAR 18-767)
What is the CPACHE opportunity (PAR 18-767)?
Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) is a National Institutes of Health (NIH) funding program led through the National Cancer Institute (NCI). It supports long-term, structured partnerships between NCI-designated Cancer Centers (CCs) and institutions that serve underserved health disparity populations and educate underrepresented students (called ISUPSs).
What is the overall purpose of CPACHE?
The program is intended to strengthen the national cancer research enterprise while directly addressing persistent gaps in cancer outcomes, research participation, training access, and community benefit for populations that have historically been left out of cancer research and cancer-care advances.
Who is CPACHE designed to bring together?
CPACHE is centered on partnerships between an NCI-designated Cancer Center and one or more ISUPS institutions. The program also emphasizes community benefit, and the opportunity description notes that faith-based and community-based organizations and other local or regional entities may be applicants or partners depending on the structure of the collaboration.
What does ISUPS mean in this program?
ISUPS refers to institutions that serve underserved health disparity populations and educate underrepresented students. These are the institutions CPACHE aims to help build research and cancer research education capacity.
What type of funding mechanism is used?
CPACHE uses a cooperative agreement mechanism (U54). This typically means NIH program staff have an active role in overseeing and shaping the work as it progresses, rather than the grant operating strictly as a hands-off award.
What does it mean that this is a cooperative agreement (U54)?
Because the award is a cooperative agreement, awardees should expect ongoing coordination with NIH staff, performance monitoring, and programmatic involvement consistent with U54 expectations.
Are clinical trials required?
No. Clinical trials are optional under this announcement. Projects may include clinical trial activities when appropriate, but they are not required.
Does CPACHE fund isolated projects or comprehensive partnerships?
CPACHE emphasizes comprehensive collaboration rather than isolated projects. It focuses on integrated work across research, education, and outreach that is designed to be durable and to last beyond the award period.
What kinds of partnership activities are commonly expected?
The program description highlights approaches such as shared leadership and decision-making, coordinated cores or shared resources, cross-institutional mentoring teams, joint seminars and training activities, and collaborative research projects that are explicitly relevant to cancer inequities affecting surrounding communities.
What are the required goals of a CPACHE partnership?
The required goals span four main areas: (1) increase cancer research and cancer research education capacity at the ISUPS institution(s); (2) increase the number of students and investigators from underrepresented populations who engage in cancer research; (3) improve the ability of the NCI-designated Cancer Center to develop and sustain robust cancer health disparities research programs while increasing the number of investigators and students doing cancer disparities research; and (4) develop and implement cancer-related activities that provide tangible benefits to underserved communities.
What does it mean to increase cancer research and education capacity at ISUPS?
This can include strengthening faculty research capability, improving access to modern methods and technologies, expanding grant readiness, building sustainable mentorship networks, and enhancing educational offerings that prepare trainees to participate in competitive cancer research.
How does CPACHE address workforce diversity?
One of the required goals is to increase the number of students and investigators from underrepresented populations who engage in cancer research, with an emphasis on recruitment, retention, training quality, and advancement.
How does CPACHE strengthen cancer health disparities research at NCI-designated Cancer Centers?
CPACHE aims to improve the Cancer Center's ability to develop and sustain robust research programs focused on cancer health disparities, while also increasing the number of investigators and students across the partnership conducting cancer disparities research.
What is expected regarding community benefit?
Community impact is a core expectation. Partnerships must develop and implement cancer-related activities that provide tangible benefits to underserved communities.
What are examples of community-oriented activities mentioned for CPACHE?
The description notes outreach, education, evidence-based interventions, research participation initiatives, navigation-related programming, or other locally responsive efforts aligned with the partnership's strengths and the community's needs.
Who is eligible to apply?
Eligibility is broad for U.S.-based organizations. Eligible applicants include multiple levels of government (state, county, city or township, special districts), independent school districts, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities, nonprofits with or without 501(c)(3) status, for-profit organizations (other than small businesses) and small businesses, and other entities as allowed.
Are certain types of institutions specifically mentioned as aligning with the ISUPS role?
Yes. The opportunity description calls out categories often aligned with the ISUPS role or community engagement role, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Can community-based or faith-based organizations be involved?
Yes. The opportunity explicitly mentions faith-based or community-based organizations as potential applicants or partners, indicating flexibility to build partnerships that match local context and population needs.
Are U.S. territories or possessions included in the eligible organization types?
Yes. U.S. territories or possessions are explicitly mentioned as potential applicants or partners.
Are federal agencies allowed to participate?
Eligible federal agencies are explicitly mentioned as potential applicants or partners.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities are not eligible to apply under this opportunity.
Can a U.S. organization include non-domestic components in the application?
No. Non-domestic components of U.S. organizations are not eligible to apply under this opportunity.
Are foreign components allowed if defined under NIH policy?
No. Foreign components, as defined by the NIH Grants Policy Statement, are not allowed. Supported activities must remain domestically based without foreign organizational components.
What topic areas does this opportunity fall under?
The opportunity is categorized under Education and Health.
What CFDA numbers are associated with CPACHE?
The opportunity is associated with multiple CFDA numbers, listed as 93.393 through 93.399, reflecting alignment with NCI programs across research, training, and related cancer initiatives.
What is the application due date listed in the provided information?
The original closing date listed for the provided record is January 11, 2021.
Does the provided information include an award ceiling or the expected number of awards?
No. The provided source information does not specify an award ceiling or the expected number of awards. Those details would typically need confirmation through the full funding announcement or current NIH/NCI postings if the program is being reissued or continued.
What is the main idea behind CPACHE partnerships?
The program is built on the idea that durable, mutually beneficial institutional partnerships can build capacity where it is most needed and can also make established cancer centers more effective in disparities-focused science, with outcomes that last beyond the award period.
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